SWOG clinical trial number
S0501

Nonmyeloablative Allogeneic Stem Cell Transplantation for Relapsed Hodgkin's or Non-Hodgkin's Lymphoma After Autologous Transplantation (A BMT Study)

Closed
Phase
Accrual
2%
Abbreviated Title
HODGKIN'S/NON-HODGKIN'S: Nonmyeloablative Allogeneic Stem Cell Transplantation
Activated
07/01/2005
Closed
01/10/2007
Participants
Limited Institutions: Allogeneic BMT Members

Research committees

Lymphoma

Treatment

Filgrastim Fludarabine Phosphate Melphalan Methotrexate Tacrolimus

Eligibility Criteria Expand/Collapse

Relapsed lymphoma (diffuse large B-cell, follicular, primary mediastinal, mantle cell, small lymphocytic or Hodgkin's); >180 days after autologous bone marrow transplantation; must have received at least one cycle of chemotherapy post-ABMT relapse; must be in CR or PR with greatest disease measurement <= 2 cm; must have a genotypically HLA-identical sibling (5/6 or 6/6 match) or unrelated donor (10/10 match) who is medically fit, has signed consent to be a donor and meets donor eligibility criteria; >= 18 years of age; PS 0-2; must have ejection fraction >=40% by MUGA scan or 2d ECHO with no significant abnormalities; must have adequate pulmonary function measured by a correlated DLCO and TLC >= 40%; must not have a history of uncontrolled seizures; must not be HIV+ or with known AIDS syndrome; no prior malignancy except basal cell or squamous cell of the skin, in situ cervical cancer, adequately treated Stage I or II cancer for which patient is in CR, or any other cancer from which patient is disease free for >= 5 years; must not have had major surgery or radiotherapy w/in 4 weeks of registration; must not be pregnant or nursing; must not have uncompensated coronary artery disease on ECG or physical exam, or previous myocardial infarction, unstable angina, or uncontrolled atrial fibrillation in the past 6 months; must not have uncontrolled hypertension; must not have clinical evidence of severe peripheral vascular disease, diabetic ulcers or venous stasis ulcers, or a history of deep venous or arterial thrombosis w/in the last 3 months; must not be requiring continuous supplemental oxygen therapy; must not have clinical evidence of CNS involvement by lymphoma

Other Clinical Trials

SWOG Clinical Trial Number
S2308

Randomized Phase III Study of Mosunetuzumab vs. Rituximab for Low Tumor Burden Follicular Lymphoma

Research Committee(s)
Lymphoma
Activated
08/01/2024
Accrual
1%
Open
Phase
SWOG Clinical Trial Number
CTSU/AHOD2131