SWOG clinical trial number
CTSU/N0147

A Randomized Phase III Trial of Oxaliplatin (OXAL) Plus 5-Fluorouracil (5-FU)/Leucovorin (CF) with or without Cetuximab (C225) after Curative Resection for Patients with Stage III Colon Cancer

Closed
Phase
Published
Abbreviated Title
Colon Ph III oxaliplatin, 5-FU, leucovorin +/- cetuximab
Activated
08/01/2004
Closed
11/25/2009
Participants
CTSU

Research committees

Gastrointestinal Cancer

Treatment

5-Fluorouracil Irinotecan Leucovorin Calcium Oxaliplatin Cetuximab Atropine Sulfate Loperamide

Eligibility Criteria Expand/Collapse

The Southwest Oncology Group endorsed this study through the Cancer Trials Support Unit (CTSU) of the National Cancer Institute.

Please contact the CTSU directly by phone (888/823-5923) or on the CTSU website (http://www.ctsu.org/) for more information and registration procedures.

Publication Information Expand/Collapse

2021

Association of Adiponectin with Tumor Infiltrating Lymphocytes in Patients with Stage III Colon Cancer Treated in an Adjuvant Chemotherapy Trial (NCCTG N0147, Alliance)

F Sinicrope;Q Shi;T Smyrk;R Goldberg;E Heying;S Cohen;S Gill;D Sha;Z Jin;M Kahlenberg;S Nair;A Shields;B Jahagirdar;N Foster;M Pollak;S Alberts J Clin Oncol 39, 2021 (suppl 15; abstr 3591) (American Society of Clinical Oncology Annual Meeting 2021, poster session)

2020

Contribution of Immunoscore and Molecular Features to Survival Prediction in Stage III Colon Cancer

F Sinicrope;Q Shi;F Hermitte;T Zemla;B Mlecnik;A Benson;S Gill;RM Goldberg;M Kahlenberg;S Nair;AF Shields;T Smyrk;J Galon;S Alberts JNCI Cancer Spectrum Apr 5;4(3):pkaa023. doi: 10.1093/jncics/pkaa023. eCollection 2020 Jun.

PMid: PMID32455336 | PMC number: PMC7236783

2018

Physical Activity and Outcomes in Patients with Stage III Colon Cancer: A Correlative Analysis of Phase III Trial NCCTG N0147 (Alliance)

AI Phipps;X Shi;T Zemla;E Dotan;S Gill;RM Goldberg;S Hardikar;B Jahagirdar;PJ Limburg;P Newcomb;A Shields;FA Sinicrope;DJ Sargent;SR Alberts Cancer Epidemiology, Biomarkers, Prevention Jun;27(6):696-703

PMid: PMID29563133 | PMC number: PMC5984710

2017

Association of micropapillary architecture and high tumor budding with prognosis in patients with stage III colon cancer from a FOLFOX-based adjuvant chemotherapy Trial: NCCTG N0147 (Alliance)

HE Lee;Q Shi;N Foster;DJ Sargent;E Chan;S Gill;M Kahlenberg;S Nair;AF Shields;RM Goldberg;SR Alberts;FA Sinicrope;TC Smyrk Mod Pathol 2017;30(S2):181A; USCAP 2017 Meeting (March 4-10, 2017, San Antonio, TX), poster

Pre-diagnostic physical activity and outcomes in patients with stage III colon cancer: A correlative analysis of phase III trial NCCTG N0147 (Alliance)

A Phipps;Q Shi;E Chan;S Gill;RM Goldberg;S Hardikar;PJ Limburg;PA Newcomb;A Shields;F Sinicrope;TJ Zemla;DJ Sargent;SR Alberts American Society of Preventive Oncology Annual Meeting (March 11-14, 2017, Seattle, Washington), poster

Analysis of serum vitamin D levels and prognosis in stage III colon carcinoma patients treated with adjuvant FOLFOX+/- cetuximab chemotherapy: NCCTG N0147 (Alliance)

F Sinicrope;Q Shi;T Smyrk;R Goldberg;W Heying;E Chan;S Gill;M Kahlenberg;S Nair;A Shields;D Sargent;M Pollak;S Alberts J Clin Oncol 35, 2017 (suppl; abstr 3516); American Society of Clinical Oncology Annual Meeting (June 2-6, 2017, Chicago, IL), poster discussion

Association of immune markers and immunoscore with survival of stage III colon cancer (CC) patients treated with adjuvant FOLFOX: NCCTG N0147 (Alliance)

F Sinicrope;Q Shi;F Hermitte;E Heying;E Chan;S Gill;R Goldberg;M Kahlenberg;S Nair;A Shields;D Sargent;J Galon;S Alberts J Clin Oncol 35, 2017 (suppl; abstr 3579); American Society of Clinical Oncology Annual Meeting (June 2-6, 2017, Chicago, IL), poster session

Genetic correlates of therapeutic toxicities of stage III colon cancer patients treated with adjuvant FOLFOX+/-cetuximab (NCCTG N0147, Alliance)

P Newcomb;M Sun;X Hua;B Banbury;A Phipps;J Kocarnik;T Harrison;Q Shi;F Sinicrope;S Thidbodeau;E Chan;S Gill;R Goldberg;M Kahlenberg;S Nair;A Shields;U Peters;S Alberts;AT Chan J Clin Oncol 35, 2017 (suppl; abstr 3604); American Society of Clinical Oncology Annual Meeting (June 2-6, 2017, Chicago, IL), poster session

Evaluation of immunoscore and immune biomarkers in stage III colon carcinoma patients treated with adjuvant FOLFOX in a phase III trial (NCCTG N0147; Alliance)

F Sinicrope;Q Shi;F Hermitte;E Heying;A Benson;S Gill;R Goldberg;MS Kahlenberg;S Nair;A Shields;S Sargent;J Galon;S Alberts Annals of Oncology Jun 1;28(suppl_3) LBA

2016

Alcohol consumption and colon cancer prognosis among participants in North Central Cancer Treatment Group phase III trial N0147

A Phipps;Q Shi;P Limburg;GD Nelson;DJ Sargent;F Sinicrope;E Chan;S Gill;RM Goldberg;M Kahlenberg;S Nair;A Shields;PA Newcomb;SR Alberts International Journal of Cancer, Sep 1;139(5):986-995; 2016 Apr 8 [Epub ahead of print]

PMid: PMID27060850 | PMC number: PMC4911257

Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance)

AM Lee;Q Shi Qian;SR Alberts;DJ Sargent;FA Sinicrope;JL Berenberg;A Grothey;B Polite;E Chan;S Gill;MS Kahlenberg;SG Nair;AF Shields;RM Goldberg;RB Diasio Pharmacogenetics and Genomics, Mar;26(3):133-137

PMid: PMID26658227 | PMC number: PMC4738010

Relationship between metformin use and recurrence and survival in patients with resected stage III colon cancer receiving adjuvant chemotherapy: results from North Central Cancer Treatment Group N0147 (Alliance)

P Singh;Q Shi;N Foster;A Grothey;S Nair;E Chane;A Shields;R Goldberg;S Gill;M Kahlenberg;F Sinicrope;D Sargent;S Alberts Oncologist Dec;21(12):1509-1521; Epub 2016 Nov 23

PMid: PMID27881709 | PMC number: PMC5153338

2015

Relationship between metformin use and recurrence and survival in patients (pts) with resected stage III colon cancer (CC) Receiving Adjuvant Chemotherapy: Results from NCCTG N0147 (Alliance).

PP Singh;Q Shi;N Foster;A Grothey;A Shields;FA Sinicrope;DJ Sargent;SR Alberts Journal of Clinical Oncology 33:5s (suppl; abstr 3531); American Society of Clinical Oncology Annual Meeting (May 29-June 2,2015, Chicago, IL), poster session;

Alcohol consumption and prognosis in patients with stage III colon cancer: A correlative analysis of phase III trial NCCTG N0147 (Alliance)

A Phipps;Q Shi;P Limburg;GD Nelson;DJ Sargent;F Sinicrope;E Chan;S Gill;RM Goldberg;M Kahlenberg;S Nair;AF Shields;PA Newcomb;SR Alberts Journal of Clinical Oncology 33:5s (suppl; abstr 1508); American Society of Clinical Oncology Annual Meeting (May 29-June 2, 2015, Chicago, IL), oral presentation;

2014

Comparison of FOLFIRI With or Without Cetuximab in Patients With Resected Stage III Colon Cancer; NCCTG (Alliance) Intergroup Trial N0147

J Huang;SG Nair;MR Mahoney;GD Nelson;AF Shields;E Chan;RM Goldberg;S Gill;MS Kahlenberg;JT Quesenberry;SN Thibodeau;TC Smyrk;A Grothey;FA Sinicrope;TA Webb;GH Farr;BA Pockaj;JL Berenberg;M Mooney;DJ Sargent;SR Alberts Clinical Colorectal Cancer 13(2):100-109;

PMid: PMID24512953 | PMC number: PMC4019685

2012

Effect of oxaliplatin, fluorouracil, and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer

SR Alberts;DJ Sargent;S Nair;M Mahoney;M Mooney;SN Thibodeau;TC Smyrk;FA Sinicrope;E Chan;S Gill;MS Kahlenberg;AF Shields;JT Quesenberry;TA Webb;GH Farr, Jr;BA Pockaj;A Grothey;RM Goldberg Journal of the American Medical Association 307(13):1383-1393

PMid: PMID22474202 | PMC number: PMC3442260