SWOG clinical trial number
S0122
Phase II Trial of Patients with Limited Stage Small Cell Lung Cancer Treated with Thoracic Radiation Therapy and Chemotherapy with Cisplatin/Etoposide Followed by Cisplatin/Etoposide and Anti-Idiotype Monoclonal Antibody Vaccines
Closed
Phase
Accrual
10%
Research committees
Lung Cancer
Treatment
Cisplatin
Etoposide
TriAb
TriGem
RT
Eligibility Criteria Expand/Collapse
Pts must have histologically/cytologically-confirmed limited SCLC (diagnosis based on sputum is acceptable); evidence of dz by Chest CT; >/= 2 weeks from surgery and recovered (dz must be present outside the area of surgical resection); pts must be willing to participate in immune studies; FEV1 and DLCO obtained; ANC >/= 1,500; PLTS >/= 100,000; PS 0-1; serum creatinine </= IULN or CrCl >/= 60 cc/min (meas. or calc.); 18 yrs or older; no other prior malignancy except: treated basal cell or squamous cell skin ca, in situ cervical ca, Stage I or II ca in complete remission (disease-free from any ca for 5 yrs.); pts with malignant pericardial or pleural effusions are not eligible; pts must not have had prior chemo, thoracic RT or biologic tx for SCLC; pts must not have received prior TriAb/TriGem or have a hx of sensitivity; pts must not have known exposure to murine antibodies or known sensitivity to rodent proteins; pts must not have CNS dz by CT or MRI of brain; pts must not have received investigational device/agent, immunotherapy, immunization or systemic corticosteroids (except as part of anti-emetic regimen) w/in 30 days or must not be planning to receive systemic corticosteroids or other immunosuppressants, etc.; pts must not have >/= Grade 1 symptomatic neuropathy-sensory; pts must not be hearing impaired and unwilling to accept further worsening; pts must not be pregnant or nursing or of reproductive potential and not agreed to use of effective contraceptive method.
Other Clinical Trials
SWOG Clinical Trial Number
S2302
PRAGMATICA - LUNG: A PROSPECTIVE RANDOMIZED STUDY OF RAMUCIRUMAB (LY3009806; NSC 749128) PLUS PEMBROLIZUMAB (MK-3475; NSC 776864) VERSUS STANDARD OF CARE FOR PARTICIPANTS PREVIOUSLY TREATED WITH IMMUNOTHERAPY FOR STAGE IV OR RECURRENT NON-SMALL CELL LUNG CANCER
Research Committee(s)
Lung Cancer
Activated
03/06/2023
Accrual
95%
Open
Phase
SWOG Clinical Trial Number
A082002
A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy with or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer
Research Committee(s)
Lung Cancer
Activated
12/21/2021
Open
Phase
SWOG Clinical Trial Number
CTSU/NRG-LU007
RAndomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial
Research Committee(s)
Lung Cancer
Activated
08/17/2020
Open