Chemoprevention of Prostate Cancer with Finasteride (Proscar®), Phase III, Intergroup (PCPT)
Treatment
Eligibility Criteria Expand/Collapse
Eligibility for enrollment: male, >= 55 years, PS=0, DRE within normal limits, no prior prostate ca, no prior finasteride or anabolic steroids, no prior systemic therapy for cancer, must not be in urinary retention or have urinary obstructive symptoms or severe prostatism.
CANCER CONTROL CREDIT: 1.0
Publication Information Expand/Collapse
2024
PMid: PMID38112776 | PMC number: PMC11343583
2023
Genetically Adjusted PSA Levels for Prostate Cancer Screening
PMid: PMID37264206 | PMC number: PMC10287565
PMid: PMID37292833 | PMC number: PMC10246022
PMid: PMID36872133 | PMC number: PMC10424812
2022
Serum Markers, Obesity and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial
PMid: PMID34889205 | PMC number: PMC8776589
PMid: PMID33511883 | PMC number: PMC8319215
Circulating Inflammatory Cytokines and Risk of Five Cancers: a Mendelian Randomization Analysis
PMid: PMID35012533 | PMC number: PMC8750876
PMid: PMID35085228 | PMC number: PMC8794090
PMid: PMID35579976 | PMC number: PMC7613289
A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry
PMid: PMID35031163 | PMC number: PMC9018520
PMid: PMID35096612 | PMC number: PMC8795906
PMid: PMID35152271 | PMC number: PMC9372232
PMid: PMID35266989 | PMC number: PMC9354799
Intake Patterns of Specific Alcoholic Beverages by Prostate Cancer Status
PMid: PMID35454886 | PMC number: PMC9024489
2021
PMid: PMID33398198 | PMC number: PMC8148035
African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer
PMid: PMID32930425 | PMC number: PMC8135907
Advancing traditional PSA kinetics in the detection of prostate cancer: A Machine Learning model
PMid: PMID34920976
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
PMid: PMID33517887 | PMC number: PMC7849104
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
PMid: PMID33623038 | PMC number: PMC7902617
PMid: PMID34258619 | PMC number: PMC8488877
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer
PMid: PMID33420416 | PMC number: PMC8157993
PMid: PMID34127801 | PMC number: PMC8669040
PMid: PMID33740060 | PMC number: PMC8168352
2020
PMid: PMID31912782 | PMC number: PMC8195110
A Meta-Analysis of Genome-Wide Association Studies of Multiple Myeloma among African Americans
PMid: PMID31935283 | PMC number: PMC6960456
PMid: PMID32102946 | PMC number: PMC7272271
PMid: PMID31776447 | PMC number: PMC7237354
PMid: PMID32581009 | PMC number: PMC7541466
PMid: PMID32409115 | PMC number: PMC7805560
PMid: PMID32506665 | PMC number: PMC7384586
PMid: PMID32546605 | PMC number: PMC7483330
Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk
PMid: PMID32967863 | PMC number: PMC8195110
PMid: PMID33158149 | PMC number: PMC7694218
2019
PMid: PMID30541042 | PMC number: PMC6579744
PMid: PMID30121626 | PMC number: PMC6379150
Long-term effects of finasteride on prostate cancer mortality [correspondence]
PMid: PMID30673548 | PMC number: n/a - correspondence/letter to editor
PMid: PMID30538099 | PMC number: PMC6365187
Mechanisms and Funding Opportunities in Genitourinary Cancer Clinical Research [Review]
PMid: PMID30072304
Shared heritability and functional enrichment across six solid cancers
PMid: PMID30683880 | PMC number: PMC6347624
Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study
PMid: PMID30352818 | PMC number: PMC6746173
PMid: PMID30425058 | PMC number: PMC6330070
PMid: PMID31589258
2018
PMid: PMID29936140 | PMC number: PMC6625804
PMid: PMID29228205 | PMC number: PMC6075364
PMid: PMID29892050 | PMC number: PMC5995836
PMid: PMID29534197 | PMC number: PMC6235685
Circadian Genes and Risk of Prostate Cancer in the Prostate Cancer Prevention Trial
PMid: PMID29318656 | PMC number: PMC5840353
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
PMid: PMID29892016 | PMC number: PMC6568012
Reduced Risk of Prostate Cancer With 5a-Reductase Inhibitors. [Editorial]
PMid: PMID29547919 | PMC number: PMCIDPMC6454440
Chemoprevention in Prostate Cancer: Current Perspective and Future Directions [Review]
PMid: PMID29311128 | PMC number: PMC6169981
Low free testosterone and prostate cancer risk: a collaborative analysis of 20 prospective studies
PMid: PMID30077399 | PMC number: PMC6195673
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
PMid: PMID30397198 | PMC number: PMC6218483
2017
PMid: PMID28446545 | PMC number: PMC5540798
PMid: PMID28417914 | PMC number: PMC5409717
PMid: PMID28317149 | PMC number: PMC5400704
PMid: PMID28754796 | PMC number: PMC5626618
Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry
PMid: PMID29117387 | PMC number: PMC5448553
PMid: PMID29281666 | PMC number: PMC5744924
2016
PMid: PMID26771888 | PMC number: PMC4841624
PMid: PMID27197965 | PMC number: PMC5501387
PMid: PMID26589415 | PMC number: PMC4724283
PMid: PMID26269564 | PMC number: PMC4826049
PMid: PMID26715424 | PMC number: PMC4779655
PMid: PMID27164191 | PMC number: PMC4956504
PMid: PMID26685908 | PMC number: PMC4837898
PMid: PMID27565902 | PMC number: PMC5241895
PMid: PMID27325488 | PMC number: PMC5497457
PMid: PMID27998216 | PMC number: PMC5455311
PMid: PMID26921328 | PMC number: PMC4873385
Evolving recommendations on prostate cancer screening [Review]
PMid: PMID27249774
PMid: PMID27385803 | PMC number: PMC5241899
2015
PMid: PMID25733274 | PMC number: PMC4348556
PMid: PMID25359302 | PMC number: PMC4282945
PMid: PMID25955319 | PMC number: PMC4425512
PMid: PMID25939516 | PMC number: PMC4537352
PMid: PMID25926387 | PMC number: PMC4491033
PMid: PMID26047319 | PMC number: PMC4536102
PMid: PMID25893825 | PMC number: PMC4475463
PMid: PMID26433556 | PMC number: PMC4593316
PMid: PMID26269564 | PMC number: PMC4592455
Effect of 5a-reductase inhibitor use on mortality from prostate cancer [Editorial/Commentary]
PMid: PMID26181178 | PMC number: PMC n/a
Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies
PMid: PMID26447150 | PMC number: PMC4625592
2014
PMid: PMID25028457 | PMC number: PMC4119542
Enhancing nurse contributions to SWOG clinical trials
PMid: PMID24559777 | PMC number: PMC3961058
PMid: PMID24748218 | PMC number: PMC4012292
PMid: PMID25085836 | PMC number: PMC4120235
Statin drug use is not associated with prostate cancer risk in men who are regularly screened
PMid: PMID24518774 | PMC number: PMC4104140
Prostate Cancer Prevention Trial: Access to a biorepository and the associated clinical data
PMid: PMID24862395 | PMC number: PMC4035700
PMid: PMID2521020 | PMC number: PMC4188122
PMid: PMID24824408 | PMC number: PMC4077907
Re: Long-term survival of participants in the Prostate Cancer Prevention Trial
PMid: PMID24914438 | PMC number: PMC4023368
2013
Projecting prostate mortality in the PCPT and REDUCE chemoprevention trials
PMid: PMID22893105 | PMC number: PMC3502695
Long term survival of participants in the Prostate Cancer Prevention Trial
PMid: PMID23944298 | PMC number: PMC4141537
PMid: PMID23315596 | PMC number: PMC3565024
PMid: PMID23813705 | PMC number: PMC3755644
PMid: PMID24055241 | PMC number: PMC3874369
PMid: PMID23720006 | PMC number: PMC3735626
Prostate cancer prevention: strategies for agent development [Review]
PMid: PMID23518594 | PMC number: n/a - review article
Survival in the prostate cancer prevention trial
PMid: PMID24224632 | PMC number: PMC4927191
2012
Finasteride reduces the risk of incident symptomatic benign prostatic hyperplasia
PMid: PMID22459892 | PMC number: PMC4059403
Health-related quality of life findings for the Prostate Cancer Prevention Trial
PMid: PMID22972968 | PMC number: PMC3529595
PMid: PMID25359302 | PMC number: PMC4282945
PMid: PMID22879203 | PMC number: PMC3467348
2011
Serum estrogen levels and prostate cancer risk in the Prostate Cancer Prevention Trial: a nested case-control study. PMID 21667068; PMC3139891
Serum phospholipid fatty acids and prostate cancer risk: results from the Prostate Cancer Prevention Trial. PMID21518693; PMC3145396
Serum lycopene concentration and prostate cancer risk: results from the Prostate Cancer Prevention Trial. PMID21335507; PMC3070045
Finasteride reduces the risk of incident symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial
Association of symptomatic benign prostatic hyperplasia and prostate cancer: results from the Prostate Cancer Prevention Trial. PMID21540324
Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention Trial PMID21771722; PMC3179424
An empirical evaluation of guidelines on prostate-specific antigen velocity in prostate cancer detection
Re: an empirical evaluation of guidelines on prostate-specific antigen velocity in prostate cancer detection [Commentary]
2010
Transition of a clinical trial into translational research: the Prostate Cancer Prevention Trial experience. PMID21149329; PMC3058741
Single nucleotide differences (SNDs) in the dbSNP database may lead to errors in genotyping and haplotyping studies. PMC2797835; PMID:19877174
Human papillomavirus types 16, 18 and 31 serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial. PMC2820385; PMID: 20142255
Transparency and reproducibility in data analysis: The Prostate Cancer Prevention Trial. PMC2883301 PMID:20173101
Androgen receptor CAG repeat length is not associated with the risk of incident symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial. PMID:19938041
Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies. PMID: 20135215
Biomarkers of systemic inflammation and risk of incident, symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial. PMC2842217;PMID:20142396
Finasteride modifies the relation between serum c-peptide and prostate cancer risk: results from the Prostate Cancer Prevention Trial. PMID:20179296
Serum oxidized protein and prostate cancer risk within the Prostate Cancer Prevention Trial. PMID 20332306; PMC2853720
Diet, supplement use, and prostate cancer risk: results from the Prostate Cancer Prevention Trial. PMID20693267;PMC2950820
Editorial Comment
Androgen receptor CAG repeat length and association with prostate cancer risk: results from the prostate cancer prevention trial PMID20952028
Prostate-specific antigen, risk factors, and prostate cancer: confounders nestled in an enigma PMID20724727; PMC2935478
2009
Prostate-specific antigen and its role on the Prostate Cancer Prevention Trial
Development of the Prostate Cancer Prevention Trial Prostate Cancer Risk Calculator
The performance characteristics of prostate-specific antigen for prostate cancer screening
Trichomonosis and subsequent risk of prostate cancer in the Prostate Cancer Prevention Trial. PMC2682694;PMID: 19117055.
Serum adiponectin, c-peptide and leptin and risk of symptomatic beign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial
Alcohol consumption, finasteride, and prostate cancer risk: results from the Prostate Cancer Prevention Trial
The performance of PSA for predicting prostate cancer after a prior negative prostate biopsy
Men with low serum cholesterol have a lower risk of high-grade prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial (Southwest Oncology Group Study S9217). PMC2877916;PMID:19887582
Cancer prevention clinical trials: assessing for disparities in recruitment in Hawaii
Chemoprevention of prostate cancer. PMID: 19524966
2008
PMid: PMID1823602
Does the level of prostate cancer risk affect cancer prevention with finasteride?
PMid: PMID18455628 | PMC number: PMC2692669
PMid: PMID18163420
PMid: PMID18267333 | PMC number: PMC2387066
The performance of prostate specific antigen for predicting prostate cancer is maintained after a prior negative prostate biopsy
PMid: PMID18550097 | PMC number: https://www.ncbi.nlm.nih.gov/pubmed/18550097
Serum steroid and sex hormone binding globulin concentrations and the risk of incident benign prostatic hyperplasia (BPH): Results from the Prostate Cancer Prevention Trial. PMC2387066; PMID: 18267333.
PMid: PMID18618736 | PMC number: PMC2564287
Integrating the predictiveness of a marker with its performance as a classifier
PMid: PMID179821157 | PMC number: PMC2939738
Does finasteride affect the severity of prostate cancer? A causal sensitivity analysis
PMid: PMID20526381 | PMC number: PMC2880822
The Prostate Cancer Prevention Trial and the future of chemoprevention. PMID: 18353157
PMid: PMID19138952 | PMC number: NIHMSID551895
PMid: PMID: 19138953 | PMC number: PMC2844801
The Southwest Oncology Group: progress in cancer research [PMID18929152]
PMid: PMID: 18928669
Predicting prostate cancer risk through incorporation of prostate cancer gene 3
PMid: PMID18707724
2007
Longitudinal analysis of sexual function reported by men in the prostate cancer prevention trial
Finasteride and high-grade prostate cancer in the Prostate Cancer Prevention Trial
Finasteride improves the sensitivity of digital rectal examination for prostate cancer detection
Finasteride decreases the risk of prostatic intraepithelial neoplasia
Race/ethnicity, obesity, health related behaviors and the risk of symptomatic benign prostatic hyperplasia: results from the Prostate Cancer Prevention Trial
Prediction of prostate cancer for patients receiving finasteride: results from the Prostate Cancer Prevention Trial
Is prostate-specific antigen velocity useful in early detection of prostate cancer? A critical appraisal of the evidence
Looking back at PCPT: looking forward to new paradigms in prostate cancer screening and prevention
Prostate-specific antigen in the early detection of prostate cancer
2006
The prostate cancer prevention trial: design, biases, and interpretation of study results
Association of erectile dysfunction and subsequent cardiovascular disease
Assessing Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial
Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase
Comparison of the operating characteristics of PSA for prostate cancer detection for finasteride and placebo in the Prostate Cancer Prevention Trial
Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevetion trial
Effect of finasteride on the sensitivity of PSA for detecting prostate cancer
Modeling the effect of a preventive intervention on the natural history of cancer: application to the prostate cancer prevention trial
Sensitivity and specificity of prostate-specific antigen for prostate cancer detection with high rates of biopsy verification
A working group classification of focal prostate atrophy lesions
PMid: PMID17001160 | PMC number: n/a
2005
Estimated impact of the prostate cancer prevention trial on population mortality
Pathological assessment of high grade tumors in the Prostate Cancer Prevention Trial (PCPT)
Prostate specific antigen (PSA) as a predictor of adverse pathological features at prostatectomy in the Prostate Cancer Prevention Trial (PCPT)
The performance characteristics of prostate-specific antigen
Operating characteristics of prostate-specific antigen in men with an initial psa level of 3.0 ng/mL or lower
Assessing benefit and risk in the prevention of prostate cancer: the prostate cancer prevention trial revisited.
Erectile dysfunction and subsequent cardiovascular disease
Individual prediction of prostate cancer based on prostate specific antigen
Long-term effects of finasteride on prostate specific antigen levels: results from the prostate cancer prevention trial
Phase III prostate cancer prevention trials: are the costs justified?
2004
Implementation of the prostate cancer prevention trial (PCPT)
Prevalence of prostate cancer among men with a prostate-specific antigen level < 4.0 ng per milliliter
Statistical design issues and other practical considerations for conducting phase III prostate cancer prevention trials
The person-years saved model and other methodologies for assessing the population impact of cancer-prevention strategies
Prostate cancer chemoprevention: an overview of United States trials
First international conference on chemoprevention of prostate cancer
The prostate cancer prevention trial: the association of study site and participant adherence interventions to the study site end-of-study biopsy rates
2003
The prostate cancer prevention trial: design, status, and promise
The influence of finasteride on the development of prostate cancer
The prostate cancer prevention trial: did the adherence interventions for the end of study biopsy really work?
2002
Energy from fat is associated with obesity in US men: results from the prostate cancer prevention trial
Biomarker-based methods for determining non-compliance in a prevention trial
Biomarker-based methods for determining noncompliance in a prevention trial
2001
The prostate cancer prevention trial: current status and lessons learned
Promoting adherence to the prostate cancer prevention trial end of study biopsy requirement
Dietary supplement use in the prostate cancer prevention trial: implications for prevetion trials.
2000
Television and news print media are effective in recruiting potential participants in a prostate cancer chemoprevention trial.
Profile of men randomized to the prostate cancer prevention trial: Baseline health-related quality of life, urinary and sexual functioning, and health behaviors.
Behavioral science research in the cooperative group setting: the Southwest Oncology Group Experience
Dietary supplement use in the prostate cancer prevention trial: implications for study findings
Letter to the Editor: RE: RE: Chemoprevention of urological cancer
Minority recruitment in the prostate cancer prevention trial
1999
Prostate cancer prevention trial (PCPT) update.
Letters to the Editor: The effect of finasteride on the prostate gland in men with elevated serum prostate-specific antigen level
Validity of short food frequency questionnaires used in cancer chemoprevention trials: results from the prostate cancer prevention trial
1998
Army and Air Force leadership in the prostate cancer prevention trial.
1997
Chemoprevention of prostate cancer: The prostate cancer prevention trial.
Utility of the enrollment period in the prostate cancer prevention trial (PCPT).
Data operations management with clinical datafax: The prostate cancer prevention trial (PCPT) experience.
Clinical Trials: A Congressional Focus of Need.
PMid: PMID10388059
1996
The prostate cancer prevention trial: Efforts to increase the recruitment of minority participants.
Prostate cancer prevention trial.
Screening for prostate cancer: Opportunities for prevention.
Chemoprevention of prostate cancer with finasteride.
The prostate cancer prevention trial.
1995
Design of the prostate cancer prevention trial (PCPT)
Chemoprevention of prostate cancer with finasteride
Chemoprevention of prostate cancer with finasteride: An Intergroup trial
Chemoprevention of prostate cancer.
1994
Chemoprevention of prostate cancer with finasteride, an Intergroup trial
Prostate cancer prevention: Risk reduction through life-style, diet, and chemoprevention
The prostate cancer prevention trial. A low-risk, high-accrual study.
1993
Chemoprevention of prostate cancer with finasteride