SWOG clinical trial number
S9900
A Randomized Phase III Trial of Surgery Alone or Surgery Plus Preoperative Paclitaxel/Carboplatin in Clinical Stage IB(T2N0), II (T1-2N1, T3N0) and Selected IIIA (T3N1) Non-Small Cell Lung Cancer (NSCLC).
Abbreviated Title
Surgery vs. Surgery/Preop Pac/Carbo in NSCLC; IB, II & selected IIIA
Participants
NCORP,
Members, Medical Oncologists, Surgeons, Pathologists, ECOG, NCCTG, RTOG, ACOSOG, NCIC-CTG, CTSU
Treatment
Paclitaxel
Carboplatin
Surgery
Patients must have histologically or cytologically confirmed diagnosis of Stage IB (T2N0), II (T1-2N1, T3N0) and selected Stage IIIA (T3N1) NSCLC; pts. must have measurable dz; pts. with symptomatic tumors (T3N0,N1) involving the superior sulcus (Pancoast Tumors) are ineligible; pts. must have adequate renal, hematologic, hepatic and pulmonary function as outlined in Section 5.0; no prior systemic chemo or RT; prior resection of lung dz is allowed provided at least five years have elapsed between surgery and registration; pts. must not have plans to receive non-protocol chemo, RT, or any other treatment for their cancer prior to progression of disease; pts. must not have post obstructive pneumonia or other serious infection or underlying med conditions; no prior allergic reactions to drugs containing cremophor; pts. must be suitable candidates for surgery as outlined in Section 7.0; pts. must be offered participation in S9925 (Lung Cancer Specimen Repository Protocol).
This study has been approved by NCI's Central Institutional Review Board.
2010
Surgery with or without preoperative paclitaxel and carboplatin in early-stage non-small cell lung cancer: Southwest Oncology Group S9900, an intergroup, randomized, phase III trial
KMW Pisters;E Vallieres;J Crowley;W Franklin;P Bunn;RJ Ginsberg;JB Putnam;K Chansky;DR Gandara Journal of Clinical Oncology 28(11):1843-1849;
PMid: PMID20231678 | PMC number: PMC2860367
2009
S9900 trial update, mature analysis
KM Pisters;E Vallieres;P Bunn;J Crowley;K Chansky;D Gandara Journal of Thoracic Oncology 4(9):suppl. 1, Abst. #E9.3, S201; 2009 (IASLC 13th World Conf on Lung Cancer, oral;
2008
Cooperative group research efforts in lung cancer: focus on early stage non-small cell lung cancer
H Wakelee;C Langer;E Vokes;J Schiller;P Bass;N Saijo;A Adjei;F Shepherd;H Choy;DR Gandara Clinical Lung Cancer 9(1):9-15
PMid: PMID18282352 | PMC number: (Reviews are not within the scope of the Public Access )
2007
S9900: surgery alone or surgery plus induction (ind) paclitaxel/carboplatin (PC) chemotherapy in early stage non-small cell lung cancer (NSCLC): follow-up on a phase III trial
K Pisters;E Vallieres;PA Bunn;J Crowley;K Chansky;R Ginsberg;DR Gandara Proc of the American Society of Clinical Oncology, Journal of Clinical Oncology 25(18S):#7520
2005
S9900: a phase III trial of surgery alone or surgery plus preoperative (preop) paclitaxel/carboplatin (PC) chemotherapy in early stage non-small cell lung cancer (NSCLC): preliminary results.
K Pisters;E Vallieres;P Bunn;J Crowley;R Ginsberg;P Ellis;B Meyers;R Marks;J Treat;D Gandara Proc of the ASCO, JCO 23(16S):624s (#LBA7012)
S9900: Preliminary "surgical" results of a phase III trial of surgery alone or surgery plus preoperative (preop) paclitaxel/carboplatin (PC) chemotherapy in early stage non-small cell lung cancer (NSCLC)
E Vallieres;KMW Pisters;J Crowley;K Chansky;P Bunn;D Gandara Lung Cancer 49 (Suppl 2):S43 (0-124)
1999
Preoperative chemotherapy in stage III non-small cell lung cancer: long -term outcome
DR Gandara;B Leigh;E Vallieres;KS Albain Lung Cancer 26:3-6
