SWOG clinical trial number
S9811

Phase II Study of Hydroxyurea for Unresectable Meningioma

Closed
Phase
Accrual
66%
Published
Abbreviated Title
Hydroxyurea
Activated
11/15/1998
Closed
06/01/2005
Participants
NCORP, Members, Medical Oncologists, Pathologists, ECOG

Treatment

Hydroxyurea

Eligibility Criteria Expand/Collapse

Histologically documented primary, recurrent or residual benign meningioma which is unresectable, biopsy slides must be available for pathology review; patient must have measurable disease by CT or MRI scan; patient must have either progressive meningioma or progressive neurologic deficit; patients with malignant meningioma or meningiomatosis are not eligible; patient should have already received radiotherapy unless radiotherapy has been refused. If prior RT, treatment must have been completed at least 6 months prior to study entry, with documented progressive disease since completion of RT. Pt. must be >= 18 years, SWOG PS 0-2, no prior cytotoxic chemo. for meningioma; prior RU-486 is allowed; prior glucocorticoids and hormone replacement therapy are allowed.

Publication Information Expand/Collapse

2010

Objective response rate of unresectable benign meningioma to hydroxyurea: Southwest Oncology Group phase II trial S9811

L Swinnen;C Rankin;EJ Rushing;L Hutchins;D Damek;G Barger Society of Neuro-Oncology 2010 Annual Scientific Meeting; poster presentation

2009

Southwest Oncology Group S9811: a phase II study of hydroxyurea for unresectable meningioma

L Swinnen;C Rankin;EJ Rushing;HF Laura;DM Damek;GR Barger Journal of Clinical Oncology 27:15s, abst.#2063