SWOG clinical trial number
SWOG-9118

Chemotherapy with FAMTX in Gastric Cancer or FMTX in Colorectal Cancer: Assessment of Pharmacodynamics with Magnetic Resonance Spectroscopy, Cellular Biochemical Pharmacology, and Cellular Pathology, Phase II

Closed
Phase
Accrual
18%
Published
Abbreviated Title
Chemotherapy with FAMTX in Gastric Cancer or FMTX in Colorectal Cancer: Assessment of Pharmacodynamics with Magnetic Resonance Spectroscopy, Cellular Biochemical Pharmacology, and Cellular Pathology,…
Activated
11/15/1991
Closed
11/15/1995

Publication Information Expand/Collapse

1994

Mechanism of 5-fluorouracil trapping in tumors - a possible model for a general process determining drug uptake.

W Wolf;CA Presant;V Waluch American Association for Cancer Research 35:432(#2577)

Association of intratumoral pharmacokinetics of fluorouracil with clinical response

CA Presant;W Wolf;V Waluch;C Wiseman;P Kennedy;D Blayney;RR Brechner Lancet 343:1184-1187

Measurement of human tumor pharmacokinetics in vivo noninvasively by 19-F magnetic resonance spectroscopy predicts clinical 5-FU sensitivity and resistance

CA Presant;W Wolf;V Waluch;R Brechner;C Wiseman;DW Blayney;P Kennedy Cancer Treatment Update:757-758

Comparison between noninvasive nuclear imaging and nuclear magnetic resonance spectroscopy (NMRS) to monitor drug biodistribution, targeting and metabolism

W Wolf;V Waluch;CA Presant;J Dowell;H Kim;A Sancho;D Palekar 6th Meeting of World Congress of Nuclear Medicine :

1993

Modulation of intratumoral (IT) 5FU pharmacokinetics (PK) by leucovorin (LV) and methotrexate (M) documented by 19F-magnetic resonance spectroscopy (MRS) initial results of Southwest Oncology Group studies 9006 and 9118.

CA Presant;M Wolf;V Waluch;B Ardalan;R Brechner;C Wiseman;DW Blayney;P Kennedy ASCO 12:201(#596)

1992

Comparison between localized and unlocalized 1 9F NMR spectroscopy for 6-fluorouracil pharmacokinetic patient studies.

V Waluch;CA Presant;W Wolf Society of Magnetic Resonance in Medicine 11:58