Pilot Study to Examine Cytogenetic Abnormalities in Patients with Acute Leukemia, Ancillary

The significance of trisomy 8 in myeloid leukemia: a Southwest Oncology Group (SWOG) study.

ML Slovak;H Gundacker;SR Wolman;FR Appelbaum American Journal of Human Genetics 69(4):232(#285)

Cytogenetically aberrant cells in the stem cell compartment (CD34+lin-) in acute myeloid leukemia.

B Mehrotra;TI George;K Kavanau;H Avet-Loiseau;D Moore II;Cl Willman;ML Slovak;S Atwater;DR Head;MG Pallavicini Blood 86(3):1139-1147

Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction.

JP Radich;KJ Kopecky;DH Boldt;D Head;ML Slovak;R Babu;J Kirk;A Lee;P Kessler;F Appelbaum;G Gehly Leukemia 8(10):1688-1695

Consistent loss of the D5S89 locus mapping telomeric to the interleukin gene cluster and centromeric to EGR-1 in patients with 5q- chromosome

L Nagarjan;J Zavadil;D Claxton;X Lu;J Fairman;J Warrington;JJ Wasmuth;AC Chinault;CE Sever;ML Slovak;CL Willman;AB Deisseroth Blood 83(1):199-208

CD56: A determinant of extramedullary and central nervous system (CNS) involvement in acute myeloid leukemia (AML). Modern Pathology 7(1):120A (#695)

AA Scott;KJ Kopecky;TM Grogan;DR Head;FA Troy, II;J Mullen;J Ya;FR Appelbaum;KS Theil;CL Willman Intl Academy of Pathology 120A(#695)/Lab Investigation 70(1):120A(#695)

HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: A previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3

AA Scott;DR Head;KJ Kopecky;FR Appelbaum;KS Theil;MR Grever;I-M Chen;MH Whittaker;BB Griffith;JD Licht;S Waxman;MM Whalen;AD Bankhurst;LC Richter;TM Grogan;CL Willman Blood 84(1):244-255

Deletion of gene for multidrug resistance in acute myeloid leukemia with inversion in chromosome 16: prognostic implications

BJ Kuss;RG Deeley;SPC Cole;CL Willman;KJ Kopecky;SR Wolman;HJ Eyre;SA Lane;JK Nancarrow;SA Whitmore;DF Callen Lancet 343:1531-1534

An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the t(8;21) (q22;q22).

JR Downing;DR Head;AM Curcio-Brint;MG Hulshof;TA Motroni;SC Raimondi;AJ Carroll;HA Drabkin;CL Willman;KS Theil;CI Civin;P Erikson Blood 81(11):2860-2865

Identification and characterization of a previously unrecognized form of acute leukemia co-expressing myeloid and natural killer (NK) cell-associated antigens (CD56).

AA Scott;DR Head;K Theil;LM Chen;MH Whittaker;CL Willman International Academy of Pathology 68:100A(#575)

Development of a highly sensitive ploymerase chain reaction detect allele loss in the 5q-chromosome.

J Fairman;D Claxton;C Willman;A Deisseroth;L Nagarajan Blood 82(10)(Suppl.1)(#123)

N-ras mutations in acute myelogenous leukemia: A review of the current literature and an update of the Southwest Oncology Group experience.

JP Radich;KJ Kopecky;F Appelbaum;CL Willman;SJ Collins Leukemia and Lymphoma 6:325-334

Activation of EVI-1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26.

K Morishita;E Paraganas;CL Willman;MH Whittaker;H Drabkin;J Oval;R Taetle;MB Valentine;JN Ihle Proc Natl Acad Sci 89:3937-3941

Chromosomal rearrangements 3' of the EV1 myeloid transforming gene activate expression in human acute myelogenous leukemia.

A Gajiar;E Parganas;CL Willman;K Morishita;J Ihle Blood 80(10)Suppl.1:256a

Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction.

G Gehly;K Kopecky;D Boldt;D Head;M Slovak;F Appelbaum;J Radich Blood 78:266a

Multiparameter analysis of acute mixed lineage leukemia: Correlation of aB/Myeloid immunophenotype and immunoglobulin and T-cell gene rearrangements with the presence of the Philadelphia chromosome translocation in acute leukemias with

IA Saikevych;DP Kerrigan;TS McConnell;DR Head;FR Appelbaum;CL Willman Leukemia 5(5):373-382

Do random (non-clonal) chromosome abnormalities in bone marrow predict a clone to come?

TS McConnell;MH Duncan;K Foucar Cancer Genetics and Cytogenetics 53:257-263

N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance.

JP Radich;KJ Kopecky;CL Willman;J Weick;D Head;F Appelbaum;SJ Collins Blood 75(4):801-807

Cloning and characterization of the (15;17) translocation break point region in acute promyelocytic leukemia.

RS Lemons;D Eilender;R Waldmann;M Rebentisch;A Frej;D Ledbetter;C Willman;T McConnell;P O'Connell Genes Chromosomes and Cancer 2:79-87

The molecular biology of acute myeloid leukemia. Proto-oncogene expression and function in normal and neoplastic myeloid cells.

CL Willman;MH Whittaker Clinics in Laboratory Medicine 10(4):769-796

Expression of the EVI-1 gene encoding a DNA-binding protein in AMLs with karyotypic abnormalities of chromosome 3q.

M Whittaker;K Morishita;C Willman;T McConnell;J Lewis;J Ihle Laboratory Investigation/Modern Pathology 62:106a

Multiparameter analysis of acute mixed lineage leukemia: Correlation of B/Myeloid immunophenotype and immunoglobulin and T-cell gene rearrangements with the presence of the Philadelphia chromosome translocation in acute leukemias with myeloid morphology.

IA Saikevych;DP Kerrigan;TS McConnell;D Head;FR Appelbaum;CL Willman Leukemia 5(5):373-382