Phase II Study of Temozolomide in Unresectable or Metastatic Gastrointestinal Stromal Tumors (GIST)

Pts must have histologic or cytologic dx of GIST that is unresectable or metastatic. Pts. must have at least one measurable lesion by x-ray, scans (CT or MRI), ultrasound, or physical exam documented 28 days prior to registration. Zubrod PS 0-2. No prior chemo for this dz except for STI-571 as adjuvant therapy or tx for met dz. No prior or concomitant RT except palliative RT. Prior surgery is allowed if at least 4 wks have elapsed and pt has recovered from all side effects. Pts w/ uterin, retroperitoneal sarcomas on non-intraabdominal leioymosarcomas are not eligible.