A Phase II Trial of R115777 (NSC #70818) in Patients with Advanced Colorectal Cancer.

Cytologically or pathologically verified diagnosis of colorectal cancer; distant metastatic disease that is not surgically curable. Pts must have measurable disease. Pts must not have received tx for disseminated disease. Pts may have received prior adjuvant chemotherapy and must be more than 4 wks beyond the last dose of chemotherapy and recovered from all toxicities. Pts may have had prior surgery for colorectal cancer and must be at least 2 wks beyond surgery and recovered from all effects of surgery. Pts may have had prior radiation, with the total area of bone marrow irradiated not exceeding 25% and must be at least 4 wks beyond end of radiation and recovered from all toxicities. Pts may have had prior adjuvant immunotherapy and must be more than 4 wks beyond the last dose and recovered from all toxicities. Pts must be able to swallow and/or receive enteral medications, no concurrent use of proton inhibitors, no brain metastases. No plans for pts to receive concurrent chemotherapy, hormonal therapy, radiotherapy, immunotherapy or any other type of therapy.