SWOG clinical trial number
S9811
Phase II Study of Hydroxyurea for Unresectable Meningioma
Closed
Phase
Accrual
66%
Published
Treatment
Hydroxyurea
Eligibility Criteria Expand/Collapse
Histologically documented primary, recurrent or residual benign meningioma which is unresectable, biopsy slides must be available for pathology review; patient must have measurable disease by CT or MRI scan; patient must have either progressive meningioma or progressive neurologic deficit; patients with malignant meningioma or meningiomatosis are not eligible; patient should have already received radiotherapy unless radiotherapy has been refused. If prior RT, treatment must have been completed at least 6 months prior to study entry, with documented progressive disease since completion of RT. Pt. must be >= 18 years, SWOG PS 0-2, no prior cytotoxic chemo. for meningioma; prior RU-486 is allowed; prior glucocorticoids and hormone replacement therapy are allowed.
Publication Information Expand/Collapse
2010
Objective response rate of unresectable benign meningioma to hydroxyurea: Southwest Oncology Group phase II trial S9811
2009
Southwest Oncology Group S9811: a phase II study of hydroxyurea for unresectable meningioma