A Phase II Trial of Infusional 5-Fluorouracil (5-FU), Calcium Leucovorin (LV), Mitomycin-C (Mito-C), and Dipyridamole (D) in Patients with Locally Advanced Unresected Pancreatic Adenocarcinoma

Stage II/III (based on AJCC Staging, Version 4) pancreatic adenocarcinoma not amenable to curative resection; PS 0-2; Meas or Eval disease; Histologically or cytologically proven ductal or undifferentiated adenocarcinoma (see protocol for acceptable histological types); No prior systemic CT/RT for pancreatic canc; No other prior malig except adeq treated basal cell or squamous cell skin canc, in situ cervical canc, adeq treated Stage I/II canc from which pt is currently in complete remission, or any other canc from which pt has been dz free for 5 yrs; >= 2 wks beyond any surgical bypass procedure & recovered from all surgical effects. A pancreatic primary canc must be estab by surgical exploration, CT scan or MRI. Pts who have unresec but localized dz are elig (determined by total occlusion or encasement > 75% of main portal vein or superior mesenteric vein, total occlusion of or > 75% circumferential encasement of superior mesenteric artery, celiac axis or common hepatic artery, right or left hepatic arteries, total occlusion of peripheral splenic vein in pts w/o evidence of cirrhosis, tumor size of >= 5 cm involving body or tail of pancreas, or enlargement of celiac axis nodes w/ subsequent biopsy to prove pathologic involvement); Pts must not have lost >15% of actual body wt. (must have an oral intake of greater than 1,200 calories/day at time of regis); Preg/nursing women are ineligible.