Randomized Phase II Study of 2nd Line FOLFIRI versus Modified FOLFIRI with PARP Inhibitor ABT-888 (Veliparib) (NSC- 737664) in Metastatic Pancreatic Cancer

Histologically or cytologically documented pancreatic adenocarcinoma. Pancreatic neuroendocrine tumors, lymphoma of the pancreas, or ampullary cancer are not eligible; Must have metastatic disease that is measurable, CT scans or MRIs of the chest, abdomen, and pelvis used to assess measurable disease must have been completed within 28 days prior to reg. CT Scans or MRIs used to assess non-measurable disease must have been completed within 42 days prior to reg.

Must not have history of brain mets; must have had one and only one prior regimen of systemic therapy for metastatic disease unless the patient received systemic therapy with gemcitabine/nab-paclitaxel for resectable or borderline/locally advanced unresectable disease and progressed with metastatic disease within 3 months of the past dose of systemic therapy; systemic therapy and chemoradiotherapy for tx of resectable, borderline resectable or locally advanced unresectable disease is allowed and does not count toward prior therapy for metastatic disease; must have completed systemic therapy at least 14 days prior to reg, any surgical procedure must have been performed at least 14 days prior to reg, and radiation therapy must be completed at least 7 days prior to reg. Patients must have recovered from major side effects of prior therapies or procedures in the opinion of the local site investigator prior to reg; must not have received prior irinotecan-based chemotherapy (e.g. FOLFIRINOX or FOLFIRI); must not have received prior PARP inhibitor therapy including, but not limited to ABT-888, olaparib, rucaparib, and BMN637; Zubrod PS of 0-1; >/= 18 years old; Within 14 days prior to reg: ANC >/ 1,500/mcL, hemoglobin >/= 9 g/dL, platelets >/= 100,000/mcL, total bilirubin </= 1.5 x IULN, serum albumin >/= 3/0 g/dL, AST and ALT </= 2.5 x IULN (pts w/liver mets may have AST and ALT of </= 5.0 x IULN), serum creatinine </= 2.0 mg/dL, normal CA19-9, BUN, alk phos, Na, K, Ca, glucose, Cl, & carbon dioxide; must not have clinically significant and uncontrolled major medical conditions including uncontrolled nausea/vomiting/diarrhea, active uncontrolled infection, symptomatic CHF (NYHA Class >/= II), unstable angina pectoris or cardiac arrhythmia, psychiatric illness/social situation that would limit compliance with study requirements; must not have active seizure or history of seizure; must be able to swallow whole capsule; complete physical exam and medical history w/in 28 days prior to reg; must not have known Gilbert's Syndrome; must not have known hypersensitivity to irinotecan, 5-FU, or leucovorin; pts of childbearing potential must have a negative pregnancy test w/in 28 days prior to reg and must not be nursing; must be willing to undergo biopsy after signed consent and prior to registration and submit tumor and blood samples Note: Core biopsy required, FNA is not an acceptable substitute for core biopsy; if archival tumor is available, pt must be willing to submit sample; must be offered the opportunity to participate in specimen banking for future use.