Single Agent Docetaxel For Metastatic Breast Cancer In Patients Aged 70 Years And Older (And In A Cohort Of Patients Younger Than 60 Years)

Women with pathologically confirmed breast cancer; 70 years or older or less than 60 years; measureable disease with distantly metastatic breast cancer (M1 disease); chest x-ray; serum creatinine and bilirubin <= IULN; SGOT/SGPT <= 1.5 x IULN; alkaline phos <= 1.5 x IULN; if there is metastatic disease to the liver, SGOT/SGPT and/or alkaline phos may be up to 2 x IULN; AGC >= 1,500/ul; hemoglobin >= 9gm/dl; platelets >= 100,000/ul; no more than one prior chemotherapy for advanced, recurrent or metastatic disease; pior adjuvant or neoadjuvant therapy OK; prior hormonal therapy OK; prior adjuvant taxanes OK; no know brain or CNS metastases; must have recovered form effects of prior RT or surgery; pharmacokinetic sampling; no known HIV; PS=0,1,2.