A Phase II Study of Observation in Favorable Low Grade Glioma and a Phase III Study of Radiation with or without PCV Chemotherapy in Unfavorable Low-Grade Glioma

Closed

Phase

Published

Abbreviated Title

Low Grade Glioma (LGG)

Activated

01/01/1999

Closed

06/27/2002

Participants

NCORP, Members, Medical Oncologists, Radiation Oncologists, Pathologists

Research committees

Brain Cancer

Treatment

Radiation Therapy PCV

Eligibility Criteria Expand/Collapse

Histologic proof of supratentorial WHO grade II astrocytoma (diffuse fibrillary, protoplasmic, or gemistocytic), oligodendroglioma, or oligoastrocytoma; KPS >= 60, Neurological Function Status < / = 3; pre and post-operative MRI scans w/ and w/o contrast must be obtained within 4 weeks of date of surgery (postop MRI not necessary in biopsy only patients), CT scans are not acceptable; no prior radiation to the brain or head/neck (unless head/neck radiation clearly excluded the brain, e.g. radiation for localized vocal cord cancer); no prior chemotherapy.

Publication Information Expand/Collapse

2014

Effect of the addition of chemotherapy to radiotherapy on cognitive function in patients with low-grade glioma: secondary analysis of RTOG 98-02

RS Prabhu;M Won;EG Shaw;C Hu;D Brachman;JC Buckner;KJ Stelzer;GR Barger;PD Brown;MR Gilbert;MP Mehta Journal of Clinical Oncology 32(6):535-541

PMid: PMID24419119 | PMC number: PMC3918537

Phase III study of radiation therapy (RT) with or without procarbazine, CCNU, and vincristine (PCV) in low-grade glioma: RTOG 9802 with Alliance, ECOG, and SWOG

JC Buckner;SL Pugh;EG Shaw;MR Gilbert;G Barger;S Coons;P Ricci;D Bullard;PD Brown;K Stelzer;D Brachman;JH Suh;CJ Schultz;J-P Bahary;BJ Fisher;H Kim;AD Murtha;WJ Curran;MP Mehta Journal of Clinical Oncology 32:5s (suppl; abstr 2000); ASCO Annual Meeting (May 30-June 3, 2014, Chicago, IL), oral session;

2012

Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802

EG Shaw;M Wang;S Coons;DG Brachman;J Buckner;K Stelzer;G Barger;PD Brown;MR Gilbert;MP Mehta Journal of Clinical Oncology 30(25):3065-3070

PMid: PMID22851558 | PMC number: PMC3732006