SWOG clinical trial number
R9802
A Phase II Study of Observation in Favorable Low Grade Glioma and a Phase III Study of Radiation with or without PCV Chemotherapy in Unfavorable Low-Grade Glioma
Abbreviated Title
Low Grade Glioma (LGG)
Participants
NCORP,
Members, Medical Oncologists, Radiation Oncologists, Pathologists
Treatment
Radiation Therapy
PCV
Histologic proof of supratentorial WHO grade II astrocytoma (diffuse fibrillary, protoplasmic, or gemistocytic), oligodendroglioma, or oligoastrocytoma; KPS >= 60, Neurological Function Status < / = 3; pre and post-operative MRI scans w/ and w/o contrast must be obtained within 4 weeks of date of surgery (postop MRI not necessary in biopsy only patients), CT scans are not acceptable; no prior radiation to the brain or head/neck (unless head/neck radiation clearly excluded the brain, e.g. radiation for localized vocal cord cancer); no prior chemotherapy.