SWOG clinical trial number
C9710

Phase III Randomized Study of Concurrent Tretinoin and Chemotherapy With or Without Arsenic Trioxide (AS2O3) (NSC #706363) as Initial Consolidation Therapy Followed by Intermittent Tretinoin Maintenance Therapy Versus Observation for Patients with Untreated Acute Promyelocytic Leukemia

Closed
Phase
Published
Abbreviated Title
APL
Activated
07/15/1999
Closed
03/29/2005
Participants
NCORP, Members, Pathologists

Research committees

Leukemia

Treatment

Cytosine Arabinoside All trans retinoic acid Daunomycin Arsenic Trioxide

Eligibility Criteria Expand/Collapse

Diagnosis of APL with proof of APL morphology (FAB M3) confirmed by RT-PCR assay; no prior systemic treatment for APL including cytotoxic chemotherapy or retinoids, non-pregnant, non-nursing.

Publication Information Expand/Collapse

2017

Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era

S Mantha;DA Goldman;SM Devlin;J Lee;D Zannino;M Collins;D Douer;HJ Iland;MR Litzow;EM Stein;F Appelbaum;RA Larson;R Stone;B Powell;S Geyer;K Laumann;JM Rowe;H Erba;S Coutre;M Othus;J Park;PH Wiernik;M Tallman Blood Mar 30;129(13):1763-1767

PMid: PMID28082441 | PMC number: PMC5374291

Mutations in Acute Promyelocytic Leukemia are Similar at Diagnosis and Relapse and ETV6 may be a Molecular Biomarker of Decreased Disease Free Survival and High Risk Disease Independent of White Blood Count

E Stein;A Viny;S Devlin;E Paietta;F Appelbaum;J Lancet;R Larson;B Powell;P Wiernik;R Levine;M Tallman International Symposium on Acute Promyelocytic Leukemia (September 24-27, 2017, Rome, Italy), oral presentation

2014

Telomere length recovery strongly predicts overall survival in acute promyelocytic leukemia (http://www.bloodjournal.org/content/124/21/2375)

M Baljevic;B Dumitriu;J-W Lee;E Paietta;J Racevskis;C Chen;E Stein;RE Gallagher;JM Rowe;F Appelbaum;B Powell;RA Larson;NS Young;M Tallman Blood 124(21):2375; American Society for Hematology (December 6-9, 2014, San Francisco, CA), poster;

Arsenic trioxide in front-line therapy of acute promyelocytic leukemia (C9710): prognostic significance of FLT3 mutations and complex karyotype

X Poire;BK Moser;R Gallagher;K Laumann;C Bloomfield;B Powell;G Koval;K Gulati;N Holowka;R Larson;M Tallman;F Appelbaum;D Sher;CL Willman;E Paietta;W Stock Leukemia & Lymphoma 55(7):1523-1532

PMid: PMID24160850 | PMC number: PMC4273565

2012

Treatment influenced associations of PML-RARa mutations, FLT3 mutations and additional chromosome abnormalities in relapse acute promyelocytic leukemia [PMID22734072]

RE Gallagher;BK Moser;J Racevskis;X Poire;CD Bloomfield;AJ Carroll;RP Ketterling;D Roulston;E Schachter-Tokarz;DC Zhou;D Chen;R Harvey;J Koval;D Sher;JH Feusner;M Tallman;RA Larson;B Powell;F Appelbaum;E Paietta;CL Willman;W Stock Blood 120(10):2098-2108

PMid: PMID22734072 | PMC number: PMC3437597

2010

Arsenic trioxide improves event-free and over-all survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710 [PMID20705755; PMC2981533]

BL Powell;B Moser;W Stock;W Gallagher;C Willman;RM Stone;JM Rowe;S Coutre;JH Feusner;J Gregory;S Couban;FR Appelbaum;MS Tallman;RA Larson Blood 116(10):3751-3757

Clonal markers in relapsed acute promyelocytic leukemia (APL): clinicopathological associations and relation to all-trans retinoic acid (ATRA) treatment on intergroup phase III trial C9710

R Gallagher;B Moser;J Racevskis;X Poire;C Bloomfield;A Carroll;R Ketterling;D Ralston;E Schachter-Tokarz;D Zhou;I-M Chen;R Harvey;G Koval;D Sher;J Feusner;M Tallman;F Appelbaum;R Larson;B Powell;E Paietta;C Willman;W Stock Blood 116:abst.#1038, 2010; American Society of Hematology Annual Mtg, poster

2008

Arsenic trioxide consolidation improves event-free and overall survival among patients with newly diagnosed acute promyelocytic leukemia: North American Intergroup protocol C9710

BL Powell;B Moser;W Stock;RE Gallagher;CL Willman;RM Stone;JM Rowe;SE Coutre;JH Feusner;J Gregory;S Couban;FR Appelbaum;MS Tallman;RA Larson Annals of Hematology 87(Suppl. 1):S77-S78

2007

Effect of consolidation with arsenic trioxide (As2O3) on event-free survival (EFS) and overall survival (OS) among patients with newly diagnosed acute promyelocytic leukemia (APL): North American Intergroup Protocol C9710

BL Powell;B Moser;W Stock;RE Gallagher;C Willman;S Coutre;JH Feusner;FR Appelbaum;MS Tallman;RA Larson Proc of the American Society of Clinical Oncology, Journal of Clinical Oncology 25(18S):#2

Prognostic significance of initial clinical and molecular genetic features of acute promyelocytic leukemia (APL): Results from the North American Intergroup Trial, C9710

W Stock;B Moser;BL Powell;FR Appelbaum;MS Tallman;RA Larson;JH Feusner;CD Bloomfield;C Willman;RE Gallagher Proc of the American Society of Clinical Oncology, Journal of Clinical Oncology 25(18S):#7016

2006

Relapse of acute promyelocytic leukemia with PML-RARa mutant subclones independent of proximate all-trans retinoic acid selection pressure

RE Gallagher;EL Schachter-Tokarz;DC Zhou;W Ding;SH Kim;BJ Sankoorikal;W Bi;KL Livak;JL Slack;CL Willman Leukemia 20:556-562

Frequent PML-RARa mutations in relapse patients on acute promyelocytic leukemia (APL) intergroup Phase III trial C9710

RE Gallagher;EL Schachter-Tokarz;BK Moser;D Sher;E Paietta;MS Tallman;C Bloomfield;B Powell;RA Larson;FR Appelbaum;CL Willman;RC Harvey Blood 108:#2342