FAQs & How to use this site
Home | About Us | Contact Us
brief timeline of SWOG history
(click image to enlarge)
SWOG is a worldwide network of researchers that design and conduct cancer clinical trials. The group's goal is to change medical practice so it improves the lives of people with cancer. SWOG trials test new ways to diagnose and treat cancer, as well as prevent it. SWOG researchers also study ways to improve the care cancer patients receive, and improve quality of life for both patients and survivors.

SWOG is a major part of the national cancer research infrastructure.

The nearly 6,000 physician researchers in the network practice at more than 950 institutions nationwide and in six other countries. The network includes 32 of the National Cancer Institute (NCI)-designated cancer centers, as well as community hospitals, private practices, and physician group networks. Formerly the Southwest Oncology Group, SWOG is one of five cooperative groups in the NCI's National Clinical Trials Network and is primarily supported through NCI grants, making it heavily dependent on federal support. For more information about SWOG visit the About Us page.

SWOG researchers routinely announce clinical trial results at major medical conferences and publish in leading scientific journals. For more information, visit the Publications page.

The 1950s
In 1955, the National Cancer Institute (NCI) formed a Clinical Studies Panel. During one of its early meetings, it was discussed that the study of leukemia would move forward more quickly if physicians worked together on clinical trials through a "cooperative group" mechanism, which would allow for broad collaboration among researchers from various medical institutions. This research method already had been proven successful in Veterans Administration hospitals when they studied tuberculosis. Several cooperative groups were organized as a result, including the Southwest Cancer Chemotherapy Study Group, which was funded in 1956 as a pediatric oncology (children's cancers) group. Its home base was in Houston, Texas.

Map of SWOG institutions in the US
SWOG sites in the United States (click image to enlarge)
In 1958, the NCI directed the Southwest Cancer Chemotherapy Study Group to study adult cancers, as well. This is important to note because today the Group studies adult cancers exclusively. The pediatric and adult divisions functioned separately with different administrative bodies. At that time, most member institutions in the Group were located in the southwestern part of the United States. Today, however, the Group's more than 500 institutions are located throughout the country, as depicted on the map at right.

The 1960s
Research in the Adult Division of the Southwest Cancer Chemotherapy Study Group began slowly, with early trials focusing on liquid cancers (leukemia, lymphoma and myeloma). In time, however, the Adult Division began to develop trials for all solid tumor cancers, with studies initiated when new agents became available.

The 1970s
The 1970s was a time of change for the Group. In 1971, the original constitution and bylaws were replaced by a constitution that more formally provided for two divisions of the Group—the Adult Division and Pediatric Division—each with its own executive committee. In early 1973, the Group established six Disease Study Committees in the Adult Division.

Southwest Oncology Group Symbol In June 1973, the Southwest Cancer Chemotherapy Study Group was formally renamed the Southwest Oncology Group. The constitution was changed to include strict performance standards to evaluate its institutions and members.

In 1976, the Group incorporated the National Cancer Institute's Affiliate Program, to give individual physicians and small physician consortia the opportunity to become affiliated with a member institution in order to conduct cancer research.

The 1980s
Even more significant changes took place during this decade. Late in 1980, the Pediatric Division sought independent status and formed the Pediatric Oncology Group. This formally changed the mission of the Southwest Oncology Group to focus solely on cancer in adults.

Dr. Coltman In March, 1981, Charles A. Coltman, Jr., M.D., was elected chairman of the Southwest Oncology Group, a position he held for 24 years. The Group experienced significant growth and accomplishments under his leadership. The Operations Office was moved from Kansas City, where it had been since 1972, to the Cancer Therapy and Research Center (CTRC) in San Antonio, Texas. Dr. Coltman led CTRC's cancer treatment and research programs.

Shortly after his election as chairman, Dr. Coltman restructured the Group. The executive committee was replaced by a board of governors made up of principal investigators and representatives of discipline committees. The Group's scientific efforts and administrative responsibilities shifted to the disease committees.

Until the early 1980s, the majority of cancer research was conducted in large university teaching hospitals. But physicians trained at academic cancer centers were increasingly entering community practice, and many cancer patients had to travel great distances to cancer centers to participate in cutting-edge clinical trials. To remedy this situation, in 1983 the Group began participating in the Community Clinical Oncology Program (CCOP), a new program launched by the NCI's Division of Cancer Prevention. The CCOP expanded the principles of the Affiliate Program, mentioned earlier, by providing community-based physicians a way to conduct cancer research, bringing the latest in investigational cancer treatments to patients in their communities and giving more patients the opportunity to participate in clinical trials. As a result, hospitals, community oncologists and other local healthcare providers were transformed into a national network to conduct clinical trials. Cooperative groups such as the Southwest Oncology Group and some cancer centers served as their research bases. CCOP institutions focus on cancer control and prevention programs in addition to treatment trials.

The CCOP program grew steadily during the 1980s, and as a result of the increased efforts in cancer control activities, the Group developed a Cancer Control Research Committee to address the need for cancer prevention, symptom management and quality-of-life research. A formal Quality Control Program was developed in connection with the CCOP program to ensure the consistent submission of high-quality data.

Dr. Crowley Another significant change in the early 1980s was the relocation of the Statistical Center from Houston, Texas, to Seattle, Wash., under the direction of newly appointed Group Statistician, John J. Crowley, Ph.D. The new Statistical Center opened its doors on October 1, 1984, on the campus of the Fred Hutchinson Cancer Research Center.

In 1988, another program was established that had a significant impact on the Group. The Urologic Cancer Outreach Program (UCOP) was established to attract more urologists into the Group and to increase enrollment of patients to genitourinary trials. In late 2007, CTRC was transferred to the University of Texas Health Science Center in San Antonio.

The 1990s
In 1990, the Southwest Oncology Group participated in the NCI's expansion of the CCOP to form the Minority-Based CCOP (MBCCOP). This program was started in an effort to provide better cancer care to minority patients in their communities and to involve more minority patients in clinical trials. Some minority populations are more vulnerable to certain types of cancer, are less likely to participate in clinical trials and often are medically underserved. The MBCCOP specifically addressed those concerns by offering membership to institutions with a 50 percent or greater minority patient population. The Sept. 13, 2005, special edition of the NCI Cancer Bulletin acknowledged the program's success, noting that over the last decade more than 5,500 minority patients have enrolled in treatment and prevention trials through the MBCCOP network. And while MCCOP institutions accounted for less than 20 percent of the CCOP network, they brought half of the minority patients into clinical trials.

In 1991, the Southwest Oncology Group established a non-profit foundation, the Southwest Oncology Group Foundation, to enable the Group to accept contributions to support its work. In 1992, a separate 501(c)(3) tax-exempt organization was formally established.

Also in 1991, the Committee on Women's Health was formed to focus on specific concerns of women in Group clinical trials. Over the years, the scope of the committee continued to evolve to also address issues concerning cancer in minorities, the aged and medically underserved populations. In 2002 the committee name was changed to the Committee on Special Populations, which would itself be superseded in 2007 by the committees within SWOG's new Cancer Control and Prevention program.

Dr. Fukushima and Dr. ColtmanMidway through 1991, Dr. Coltman met with a leading physician from Japan, Masanori Fukushima, M.D., Ph.D. The purpose of their meeting was to establish a program to encourage researchers from the United States and Japan to work together to enhance the quality of Japanese clinical trials. The first United States - Japan Cancer Clinical Trials Summit was held in 1992. In succeeding years, participation in the summits grew to include premier cancer physicians from throughout the United States, Canada and Japan. The meetings focused on reviewing and exchanging information about clinical trials on a broad range of cancers including urological, gynecological, head and neck, esophageal, gastric, colorectal, and multiple myeloma, as well as bone and soft tissue sarcomas.

Prostate Cancer Prevention Trial (PCPT)In October 1993, the Southwest Oncology Group launched the first large-scale prevention trial for prostate cancer. The Prostate Cancer Prevention Trial (PCPT) was a double-blind study designed to evaluate whether taking the drug finasteride would prevent prostate cancer. More than 18,000 men were enrolled at over 220 sites located throughout the United States.

The trial was closed early on June 24, 2003, because of a finding that finasteride reduced the incidence of prostate cancer. The analysis of the data revealed that men in the finasteride group who were evaluated by means of a prostate biopsy were 24.8 percent less likely to develop prostate cancer when compared to the men evaluated in the placebo group. However, those trial participants who did develop prostate cancer while taking finasteride had a slightly higher incidence of high-grade tumors. The results of the study were published in the New England Journal of Medicine in 2003. Ten years late, the same journal published long-term results from PCPT, which showed an even more pronounced association of finasteride with a reduced risk of low-grade cancer diagnoses and showed no difference in overall mortality across the arms. Twenty years after PCPT was launched, the debate over possible chemopreventive use of finasteride continued, and dozens of additional peer-reviewed papers and abstracts related to the study have been published. For more information see the PCPT Page.
The Hope Foundation

In 1998 the Southwest Oncology Group Foundation was formally renamed The Hope Foundation, to represent the international impact and vision of the Group.

In March 1999, an innovative program was developed by the Southwest Oncology Group to foster the role of young clinical investigators beginning a career in cancer clinical trials. The first Southwest Oncology Group Young Investigators Training Course was conducted in 2000. The intensive program, conducted annually, focuses on statistical principles, data collection and analysis, critical decision making, protocol development and other Group procedures. Each year a competitive application process is employed to select the young investigators who are invited to attend the course.

The 2000s
Selenium and Vitamin E Cancer Prevention Trial (SELECT)On July 25, 2001, the largest-ever prostate cancer prevention trial, the Selenium and Vitamin E Cancer Prevention Trial (SELECT), was launched. SELECT was a phase III, double-blind, placebo-controlled four-arm study of selenium, vitamin E, selenium and vitamin E together, and placebo designed to assess the effect of these supplements on the incidence of prostate cancer. The study quickly exceeded its accrual goal, enrolling 35,533 men at 427 sites in the U.S. and Canada in just 33 months. Participants were healthy men age 55 and older (50 and older for African-American men) with no history of prostate cancer. In the fall of 2008, the trial's Data Safety and Monitoring Committee recommended that participants discontinue taking study supplements based on an interim finding of no preventive benefit for any of the arms. In 2009-2010, more than half of the 30,000+ participants remaining on SELECT were transitioned to centralized follow-up. In late 2011, SELECT researchers reported an unexpected long-term finding: men on the vitamin E only arm of the trial ran a 17 percent higher risk of prostate cancer than men on the placebo arm. The central hypothesis of the study had been turned on its head, though the biospecimens and associated clinical data collected as part of the trial continue to provide raw materials for important translational research and are likely to do so for years to come.

Dr. BakerOn May 27, 2003, Dr. Coltman informed the Board of Governors that he would not seek re-election as Group chair. This set in motion the selection of a chair-elect, who would assume the chairmanship when Dr. Coltman's term expired at the spring 2005 Board of Governor's meeting. Several candidates were nominated and on July 2, 2003, the Board of Governors elected Laurence H. Baker, D.O., the next chair. Dr. Baker, who served as associate chair during Dr. Coltman's tenure, is professor of Internal Medicine and Pharmacology at the University of Michigan in Ann Arbor, Michigan.

Drs Erba, Redman, and SchottAt the fall 2003 Group meeting in Seattle, Dr. Baker announced that a new Headquarters Office would be established at the University of Michigan. He also introduced three University of Michigan faculty members as the Group's new executive officers, who would oversee the development and conduct of Group protocols: Harry P. Erba, M.D., Ph.D.; Bruce G. Redman, D.O.; and Anne F. Schott, M.D.

The spring 2005 Group meeting brought a new milestone for the Group. On April 8, 2005, Dr. Coltman stepped down as Group chairman and Dr. Laurence H. Baker became the new Group chair. Dr. Coltman then served as associate chair for cancer control and prevention for the Group until September 2007, at which time he was appointed chair emeritus.

Dr. FisherOne of Dr. Baker's first priorities as Group chair was to reorganize the Scientific Advisory Board, naming Richard I. Fisher, M.D., chair and expanding the board to include external advisors. Dr. Fisher has been a member of SWOG since 1985 and chair of the Lymphoma Committee since 1988. At the fall 2005 Group meeting, Dr. Baker announced that Dr. Fisher had been appointed as Deputy Group Chair.

The Hope Foundation LogoJo HornWith Dr. Baker's election as Group Chairman, the Scientific Advisory Board made the decision to move The Hope Foundation office from the Operations Office to the Headquarters Office. Dr. Baker serves as the Foundation's president, Dr. Coltman is chair, and Jo Horn, M.S.W., is director. In 2006 the Hope Foundation logo and Web site were redesigned to reflect a new vision for the organization.

The Group celebrated its 50th anniversary during the Fall 2006 Group Meeting in Seattle, Washington. The plenary session featured four prominent cancer researchers who brought the Group up to date on the NCI's plans for its cancer treatment and prevention programs, as well as future directions of the American Society of Clinical Oncology. Former Group leaders and administrators were guests during the plenary session and at the 50th anniversary celebration that evening.

Dr. Carolyn HobanIn November 2006, Carolyn Hoban, D.Sc., joined the Group's executive officer team, overseeing the Group's Cancer Control and Prevention Committee and Translational Medicine Committee. She also supervises the Group's tumor and tissue banks.

As NCI funding levels fell and more SWOG trial proposals were denied by the NCI because of funding considerations, SWOG stepped up efforts to attract additional monies from external organizations. To allow worthy investigator-initiated trials to proceed even when the NCI had declined to fund them, the Group organized the SWOG Clinical Trials Initiative (SWOG-CTI). Founded for the express purpose of accepting non-federal dollars to support clinical trials, SWOG CTI is a limited liability company whose sole member is The Hope Foundation.

In September 2007, Frank L. Meyskens, Jr., M.D., from the University of California-Irvine Medical Center, was appointed Associate Chair of Cancer Control and Prevention. Dr. Meyskens, an international expert known for groundbreaking efforts to control and prevent cancer, would head all cancer control and prevention efforts for the Group. Dr. Meyskens presented the structure of the reorganized program at a February 2008 retreat, with stated goals of increasing the program's representation in disease committees, reaching out to clinical pharmacology, and developing training in cancer prevention and control for the next generation of SWOG investigators. The new Cancer Control and Prevention Program comprised these five committees:

  • Prevention Committee
  • Health Disparities and Outcomes Committee
  • Molecular Epidemiology Committee
  • Cancer Survivorship Committee
  • Symptom Control and Quality of Life Committee

At the fall 2008 Group Meeting, Drs. Baker and Crowley were unanimously re-elected as Group Chair and Group Statistician, with their new four-year terms beginning in April of 2009.

2008 also saw a reconfiguration of SWOG's Patient Advocates Program, placing one or more advocates in each disease committee. To ensure advocates would be integrated quickly into the work of their committees, committee chairs were invited to nominate those advocates who would sit on their committee.

At a February 2008 committee review retreat, SWOG began work on its treatment grant competitive renewal application, due to the NCI's Cancer Therapy Evaluation Program (CTEP) the following year. By the end of 2009, NCI's CTEP had formally renewed SWOG's core treatment grant for the period 2010 through 2015, with a total package of SWOG grants from CTEP, including U10 grants going to its core member institutions to support their work with the Group, projected to be worth more than $120 million over the six-year award period.

M. Valdivieso, M.D.

In late 2009, the Group brought Manuel Valdivieso, M.D. on to its leadership team, in part to lay the groundwork for more long-term collaboration with oncologists and cancer centers internationally. The Group's treatment grant renewal late in 2009 included the first U10 grant for a SWOG member outside the US -- the University of British Columbia's cancer center in Vancouver. SWOG would expand in a southerly direction the following year, with the official membership in 2010 of Mexico's Instituto Nacional de Cancerologia (INCan), that country's equivalent of the U.S.'s National Cancer Institute.

The centerpiece of SWOG's international initiatives at this time was a trial funded by a $2.5 million grant from the Bill and Melinda Gates Foundation and conducted across seven nations in Central and South America to compare the effectiveness of three antibiotic regimens against infection with the Helicobacter pylori bacterium, which is associated with gastric cancer, one of Latin America's deadliest. The trial reached its accrual goal of more than 1,400 patients by 2010. Results reported in The Lancet the following year contradicted the findings of similar studies conducted in Europe or Asia, suggesting that any future public health campaign to reduce gastric cancer risk by tackling H. pylori infections would need to carefully tailor antibiotic treatment regimens based on local conditions.

SWOG partnered in 2009 with several institutions in a successful bid for $4 million in NCI funding to develop the Center for Comparative Effectiveness Research in Cancer Genomics, or CANCERGEN. CANCERGEN's mission is to create a comprehensive evaluation, assessment, and design process to identify which emerging cancer genomics technologies are the top candidates for study by SWOG's clinical trials network.

The 2010s
January 1, 2010 marked the official move of SWOG's Operations Office from the University of Texas to administrative control of The Hope Foundation. Operations Office employees moved to a new facility -- still in San Antonio, Texas -- and became employees of The Hope Foundation. The CTEP grant funding the Operations Office was also transferred to Hope.

SWOG logo: Leading cancer research. Together.

After several decades as a nationwide -- even international -- network, SWOG in 2010 dropped the qualifier "Southwest" from its name. Group Chair Laurence Baker, D.O., announced at the Chicago group meeting in October of that year that the Southwest Oncology Group would henceforth be known simply as "SWOG." In conjunction with this change in name, the Group Chair's office sent a survey in late summer to the entire membership asking them to vote on new candidate logos and tag lines for the Group. SWOG members overwhelmingly chose a version of the Group's existing graphical mark -- the white double helix in a blue circle. This circle appears in the new logo with new typography and the Group's new tag line -- "Leading cancer research. Together."

2010 was a watershed year for the NCI's cooperative group system, with the issuance of a report from the Institute of Medicine (IOM) recommending fundamental changes and consolidation within the system. By early 2011, the other cooperative groups in adult cancer had all announced mergers or federations; eight would join to form three. SWOG's leadership made the decision not to merge, instead investing in growth in different directions.

In 2011, the group welcomed the first NCI basic science cancer center member of a cooperative group, partnering initially with Cold Spring Harbor Laboratory (CSHL) and the following year with The Jackson Laboratory (JAX) as well.

Additionally, SWOG reached out to develop partnerships internationally, especially in Latin America. Following up its partnership with Mexico's INCan, SWOG approved membership for the national cancer institutes of Brazil, Colombia, and Peru in 2012. The National Cancer Center of Korea also joined the group.

Immediately following the fall 2011 group meeting, Group Chair Laurence H. Baker, D.O., announced that he would not seek reelection to a third term when his current term expired in 2013. Coupled with this, he proposed moving up the election of the next group chair to the spring of 2012, giving a chair-elect a full year to learn the job and to lead development of the treatment grant application that would be due at the start of 2013.

Charles D. Blanke, M.D.On Saturday, April 14, 2012, at the group meeting in San Francisco, SWOG's Board of Governors elected Charles D. Blanke, M.D., to be SWOG chair-elect and to succeed Dr. Baker as Group Chair the following spring. A member of SWOG since 1999, Blanke had served as chair of the group's Gastrointestinal Committee since 2003.

On his election, Blanke stated his two priorities for the group would be patient-centered research that focused on outcomes, processes, and issues that are most important to the patient, and cancer research driven by an understanding of molecular pathways.

At the same spring 2012 session, SWOG's Board of Governors also confirmed the nomination of Michael LeBlanc, Ph.D., as SWOG's new group statistician, replacing John J. Crowley, Ph.D., who stepped down as group statistician after 28 years in the role.

In 2011, after reviewing several candidate institutions, SWOG selected Nationwide Children's Hospital Biopathology Center in Columbus, Ohio, to be home to a consolidated SWOG Biorepository, bringing together more than 300,000 tissue and blood specimens that had previously been stored in multiple facilities scattered across the country. It would also serve as collection point for SWOG study biospecimens going forward, and was expected to eventually be home to the more than 200,000 additional specimens SWOG had collected from participants in its cancer control and prevention trials. Key in making this decision was James M. Rae, Ph.D., who in 2011 replaced Carolyn Hoban, Ph.D., as SWOG executive officer with responsibility for translational medicine.

map showing locations of SWOG senior leaders and work sites
Distribution of SWOG leadership and operations (click image to enlarge)

Several committee leadership positions turned over in 2011-2012. Robert Z. Orlowski, M.D., Ph.D., was named new chair of SWOG's Myeloma Committee after long-time chair Bart Barlogie, M.D., stepped down. To recognize the foundational contributions that Barlogie and his predecessor in that position, Sydney Salmon, M.D., had made to improving the treatment of myeloma, the committee was formally renamed and is now the Barlogie-Salmon Myeloma Committee.

Harry Erba, M.D.,Ph.D., was appointed chair of the Leukemia Committee, replacing Frederick Appelbaum, M.D., who retired from that role after 22 years of service to the committee. And in the Melanoma Committee, Vernon Sondak, M.D., and Lawrence Flaherty, M.D., stepped down after more than two decades as chair and vice-chair. Antoni Ribas, M.D., and William E. Carson, III, M.D., were appointed to those positions, respectively. Also in this time frame, the Nursing Committee and the Clinical Research Associates Committee were merged into a combined Oncology Research Professionals Committee. Finally, following up on the recommendation of a task force, Dr. Baker announced a new Imaging Committee for the group with Lawrence H. Schwartz, M.D., as chair. The year 2012 closed with news that the NCI's Division of Cancer Prevention had renewed SWOG's CCOP Research Base grant for a total of $18.4 million over three years.

Sometime in 2012, SWOG's database of trials, which houses records from 45 years worth of studies, added its 1,000th SWOG clinical trial. Throughout the summer and fall of that year, numerous SWOG leaders and staff contributed to the assembly of SWOG-related applications for grants that would ensure a continued role for the group within the NCI's nascent National Clinical Trials Network in years to come. Applications were submitted for a January 2013 deadline. Reviews and scores came in in July, with the SWOG Statistical Center grant scoring in the "exceptional" range and the Network Operations Center and Integrated Translational Science Center grant applications rated "outstanding." It would still be some months before the group would see how those impressive ratings would translate into continued financial support for SWOG's work.

Development of the core Network Operations Center grant had been led by Dr. Blanke, and he officially took the Group Chair's gavel from Dr. Baker at the spring 2013 group meeting in San Francisco. He named Anne F. Schott, M.D., formerly an executive officer for the group, as Deputy Chair, and MD Anderson's Lee M. Ellis, M.D., as Vice-Chair for Translational Medicine. SWOG members at the spring meeting got a chance to see some of the new group leadership team in action. Executive Officers Gralow, Kachnic, Nichols, O'Brien, and RyanThat team included new executive officers Julie Gralow, M.D., Lisa Kachnic, M.D., Craig Nichols, M.D., Susan O'Brien, M.D., and Christopher Ryan, M.D., in addition to continuing executive officers Manuel Valdivieso, M.D., and James M. Rae, Ph.D.

Blanke also took the spring meeting as an opportunity to get a number of initiatives underway, including forming a new Adolescents and Young Adults (AYA) Committee. The Patient Advocate Committee (formerly a "program") was formally approved by the Board of Governors as SWOG's newest administrative committee. Other new teams included an Innovation Working Group, a Veterans Affairs Working Group, a Social Media Working Group, and a Rare Cancer Task Force.

In 2013, The Hope Foundation marked 20 years as the philanthropic arm of SWOG. From its modest founding by SWOG leaders in 1993, it had grown to manage assets in excess of $30 million. In its first 20 years, the Foundation channeled $21 million to SWOG educational and research initiatives.

The year 2013 saw the appointment of Howard Hochster, M.D., as new chair of the Gastrointestinal Committee (a position formerly held by Dr. Blanke) and of Patrick Stiff, M.D., as new chair of the Bone Marrow and Stem Cell Transplantation Committee. It also saw the signing of SWOG's first formal intellectual property (IP) agreement that would ensure a share of any profit coming from development of a new product built in part on SWOG research would come back to the Group to support future research to improve the practice of medicine in preventing, detecting, and treating cancer.


Revised August 2013.


brief timeline of SWOG history

For the more detailed history of SWOG, see the Official Group History.

SWOG Logo Disclaimer | Copyright ©2000-2017 SWOG. All rights reserved.
Design by nuMedia Group Inc. | Hosting by WorldPost Technologies, Inc.
SWOG is FISMA CertifiedSWOG is FISMA Certified